ASSESSMENT OF ANTIMYCOBACTERIAL AND SENSITIZING ACTIVITY OF BIOLOGICALLY ACTIVE SUBSTANCES OF EXTRACTS OF ACHILLEA MILLEFOLIUM AND ACHILLEA MICRANTHA
Abstract and keywords
Abstract (English):
The literature data revealing the general idea of the biological activity of plant raw materials of representatives of the genus Achillea are analyzed. 48 compounds the extracts of the plant Achillea micrantha identified by the method of gas chromatography and mass spectrometry. It was shown that the complex of detected compounds in Achillea micrantha extracts had a pronounced inhibitory effect against all studied strains of mycobacteria: Mycobacterium tuberculosis and Mycobacterium lufu. Rifampicin was used as a control. The proofs of the absence of the sensitizing effect of the studied extracts on experimental animals are presented. Therefore, extracts of the genus Achillea do not induce allergic reactions and are not inherently potential allergens.

Keywords:
yarrow, Achillea micrantha, biologically active substances, terpenoids, antimycobacterial activity, extraction
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References

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